Article Text

G405(P) To evaluate and compare the efficacy of combined sucrose and non-nutritive sucking for analgesia in newborns undergoing minor painful procedure: A randomised controlled trial
  1. P Thakkar1,
  2. K Arora2,
  3. K Goyal2,
  4. R Das3
  1. 1Pediatrics, Baroda Medical College, Baroda, India
  2. 2Pediatrics, Dayanand Medical College and Hopital, Ludhiana, India
  3. 3Pediatrics, All India Institute of Medical Sciences, Bhubneshwar, India


Aim Neonates frequently undergo minor painful procedures for which they are often not offered any analgesia. Sucrose and Non-nutritive sucking (NNS) can be effective non-pharmacological methods for pain relief in neonates. Aim of the study was to evaluate and compare the efficacy of combined sucrose and non-nutritive sucking for analgesia in newborn infants undergoing minor painful procedure.

Methods This randomised control trial (RCT) was conducted in the neonatal intensive care unit of a tertiary care hospital over a period of one year. 180 full term neonates with birth-weight >2200 g and age >24 h were randomised to one of four interventions administered two min before the procedure: 2 ml of 30% sucrose (group I, n = 45) or non-nutritive sucking (NNS) (group II, n = 45) or both (group III, n = 45) or none (group IV, n = 45). Primary outcome was composite score based on Premature Infant Pain Profile (PIPP) score.

Results Baseline variables were comparable among the groups. Mean (±SD) PIPP score was 3.42 ± 1.6 in group III, 7.47 ± 1.6 in group I, 8.42 ± 2.5 in group II, and 12.49 ± 2.9 in group IV. Group III had significant decrease in the mean PIPP score compared to other groups (p = 0.001). Mean PIPP score also decreased significantly with any intervention as compared to no intervention (p = 0.001).

Conclusions Sucrose and NNS in combination are effective in providing analgesia in full term neonates undergoing minor painful procedure, with the combined intervention being more effective than single intervention.

Statistics from

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.