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CHANGING PRESCRIBING CULTURE – A FOCUS ON CODEINE POSTPARTUM
  1. Noor Al-Adhami1,
  2. Karen Whitfield1,2,
  3. Angela North2
  1. 1 Royal Brisbane and Women's Hospital, Australia
  2. 2 School of Pharmacy, The University of Queensland

    Abstract

    Aim To eliminate the prescribing of codeine and codeine combination products postpartum to improve safety in breast fed infants.

    Concerns have been raised over the use of codeine and codeine combination products during breast feeding after the death of a neonate whose mother had been prescribed codeine postpartum. High concentrations of morphine were found in the infant's blood and this was attributed to the mother being a CYP2D6 ultrafast metaboliser.1

    Methods The evidence surrounding the safety of codeine and codeine combination products in children, during the postpartum period and specifically for breast fed infants was collated. The evidence was presented to key stakeholders including obstetricians, midwives, safety and quality representatives, nurse unit managers and acute pain team representatives. Postpartum analgesia was discussed and an agreed protocol developed. Training and education sessions were undertaken to obstetric medical and nursing staff.

    Results The evidence that was presented to key stakeholders included:

    ▸ Reports over the safety concerns surrounding the use of codeine and codeine combination products during breast feeding

    ▸ Guidelines and contraindications about the use of codeine in children that had been issued by international regulatory bodies (US Food and Drug Administration and European Medicines Agency).

    ▸ Recommendations from the Australian Medicines Handbook to avoid in breast feeding2

    ▸ Recommendations from Hale's Medications and Mothers Milk that reported limited data and had made a recent re-classification from L3 (limited data–probably compatible) to L4 (limited data–possibly hazardous).3

    Before presenting the evidence to key stakeholders and undertaking training to nursing and medical staff, more than 90% of postpartum women were prescribed a codeine containing product as part of their ‘as required’ analgesic regimen.

    Since the intervention, codeine combination products have now been almost completely eliminated on medication charts for postpartum women (less than 5%). Those that are prescribed are ceased once highlighted to medical staff. The obstetric pharmacist now presents a session on postpartum analgesia at every new resident medical officer orientation outlining suitable medications to prescribe. In addition all new pharmacists to the women's and new born's team receive training about postpartum analgesia.

    Conclusion This study highlights the impact that can be achieved when health care professionals work together to change the culture and prescribing habits in a hospital setting, to enhance patient safety. Evaluating the evidence and presenting to stakeholders as well as providing ongoing training and education to medical, nursing and pharmacy staff are all essential to a successful outcome.

    • Abstract
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