Introduction Delayed gentamicin delivery through intravenous lines has been reported.Delay is expected to be greater in smaller neonates when the flow rate of carrier intravenous fluid and dose volumes are low.
Aim To investigate the effects of neonate GA and weight on gentamicin peak concentrations after 30 minute infusion or bolus administrations.
Methods Neonates admitted to Dunedin Neonatal Intensive Care Unit in 2008 and 2010 who received gentamicin (2008: 30 minute infusion; 2010: slow bolus) in the first three days of life were included. Peak concentrations were compared and correlations between concentration and weight were investigated over GA bands.
Results There were 151 neonates in 2010 and 118 neonates in 2008. Median (range) GA was 38 weeks (24–42) in 2010 and 34.7 weeks (23.4–42.1) in 2008. Median (range) weight was 3.25kg (0.51–5.65) in 2010 and 2.67kg (0.49–5.11) in 2008. Peak gentamicin concentrations (mg/L) were 8.15±0.098 (at 1.2±0.32h) in 2010 and 9.92±0.17 (at 1.34±0.4h) in 2008. A test for equal variances showed peak concentrations were more variable in 2008 (p0.05).
Conclusions Peak concentrations were more variable following 30 minute infusions and were positively correlated with GA or weight for neonates with GA.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.