Table of contents

Abstracts from the 15th Congress of the European Society for Developmental, Perinatal and Paediatric Pharmacology, held in Belgrade, June 2015.

ORAL PRESENTATIONS

• OP 001: THE ONTOGENY OF P-GLYCOPROTEIN IN THE DEVELOPING HUMAN BLOOD BRAIN BARRIER: IMPLICATION FOR OPIOID TOXICITY IN NEONATES (14 December, 2015)

  Gideon Koren, Jessica Lam, Lauren Kelly, Stephanie Baella, David Chitayat, Patrick Shannon, Stephen Matthews
• OP 002: PEDIATRIC DRUG TRIALS IN CHINA (14 December, 2015)

  Guo-Xiang Hao, Xiao-Ling Wang, A-Dong Shen, Evelyne Jacqz-Aigrain, Wei Zhao
• OP 003: HEPATIC TRANSPORTER PROTEIN EXPRESSION IN FETUSES, NEONATES AND YOUNG INFANTS (14 December, 2015)

  Miriam Mooij, Evita Van de Steeg, Heleen Wortelboer, Wouter Vaes, Dick Tibboel, Saskia De Wildt
• OP 004: HOW DOES THE IN VIVO BILIARY ELIMINATION OF DRUGS CHANGE WITH AGE? EVIDENCE FROM CLINICAL DATA USING A SYSTEMS PHARMACOLOGY APPROACH (14 December, 2015)

  Trevor Johnson, Karen Rowland-Yeo, Masoud Jamei, Amin Rostami-Hodjegan
• OP 005: PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELS FOR ADULT AND PAEDIATRIC CHRONIC HEART FAILURE PATIENTS USING THE EXAMPLE OF CARVEDILOL TREATED PATIENTS (14 December, 2015)

  Muhammad Rasool, Feras Khalil, Stephanie Läer
• OP 006: INVASIVENESS OF PHARMACOKINETIC STUDIES IN CHILDREN–A SYSTEMATIC REVIEW (14 December, 2015)

  Mohammed Altamimi, Helen Sammons, Imti Choonara
• OP 007: PHARMACEUTICAL CARE OF ADOLESCENTS WITH DIABETES MELLITUS TYPE 1: THE DIADEMA STUDY, A RANDOMIZED CONTROLLED TRIAL (14 December, 2015)

  Emina Obarčanin, Manfred Krueger, Petra Mueller, Verena Nemitz, Holger Schwender, Sniježana Hasanbegović, Sena Kalajdzisalihovic, Stephanie Läer
• OP 008: QUALITY ASSESSMENT OF ANTIBIOTIC PRESCRIPTIONS IN PAEDIATRIC PRIMARY CARE SETTINGS IN SERBIA, USING EUROPEAN QUALITY INDICATORS (14 December, 2015)

  Bojana Božić, Milica Bajčetić
• OP 009: NEW QUALITY INDICATORS FOR PAEDIATRIC ANTIBIOTIC PRESCRIBING IN PRIMARY CARE: A POPULATION BASED COHORT STUDY IN THE UNITED KINGDOM, ITALY AND THE NETHERLANDS FROM 1995–2010 (14 December, 2015)

  Florentia Kaguelidou, Sandra de Bie, Katia Verhamme, Maria de Ridder, Gino Picelli, Sabine Strauś, Carlo Giaquinto, Bruno Stricker, Julia Bielicki, Mike Sharland, Miriam Sturkenboom
• OP 010: FIVE YEARS ON: A COHORT STUDY OF YOUNG PEOPLE TREATED WITH ANTIPSYCHOTIC DRUGS WHO WERE TRANSITIONING FROM CHILD TO ADULT MENTAL HEALTH SERVICES IN THE LOMBARDY REGION, ITALY (14 December, 2015)

  Laura Reale, Antonio Clavenna, Rita Campi, Massimo Cartabia, Maurizio Bonati
• OP 011: MEDICATION USE IN NEONATAL INTENSIVE CARE UNITS ACROSS EUROPE (14 December, 2015)

  Inge Mesek, Georgi Nellis, Jana Lass, Irja Lutsar
• OP 012: AVAILABILITY OF PEDIATRIC FORMULATIONS FOR THE 100 MOST PRESCRIBED DRUGS IN PEDIATRIC AMBULATORY CARE – 2002 VS. 2010 (14 December, 2015)

  Victoria C. Ziesenitz, Johannes N. van den Anker, Maryann Amirshahi
• OP 013: PERSONALIZATION OF 6-MERCAPTOPURINE THERAPY FOR CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA (14 December, 2015)

  Goran Milošević, Lidija Dokmanović, Nada Krstovski, Jelena Lazić, Predrag Rodić, Sonja Pavlović, Branka Zukić, Nikola Kotur, Dragana Janić
• OP 014: EUROPEAN PAEDIATRIC ONCOLOGY OFF-PATENT MEDICINES CONSORTIUM (EPOC): A PHARMACOKINETIC STUDY OF DOXORUBICIN IN CHILDREN WITH CANCER (14 December, 2015)

  Miriam Krischke, Alan V Boddy, Georg Hempel, Swantje Völler, Nicolas André, Mauricio D'Incalci
• OP 015: WHAT IS THE APPROPRIATE VALGANCICLOVIR DOSAGE IN CHILDREN WITH SOLID ORGAN TRANSPLANT? A PROSPECTIVE PHARMACOKINETIC STUDY (14 December, 2015)

  Orit Peled, Liat Ashkenazi-Hoffnung, Eran Rom, Efraim Bilavsky, Yael Bernfeld, Lev Dorfman, Jacob Amir, Nurit Brandriss, Adina Bar-Haim, Matitiahu Berkovitch
• OP 016: ORGAN FAILURE AND C-REACTIVE PROTEIN BOTH AFFECT MIDAZOLAM CLEARANCE IN CRITICALLY ILL CHILDREN: A POPULATION PK MODEL (14 December, 2015)

  Nienke J Vet, Janneke M Brussee, Matthijs de Hoog, Miriam G Mooij, Carin WM Verlaat, Dick Tibboel, Catherijne AJ Knibbe, Saskia N de Wildt
• OP 017: DOSE-FINDING STUDY AND PHARMACODYNAMIC ASSESSMENT OF PROPOFOL FOR (SEMI-)ELECTIVE INTUBATION IN NEONATES (14 December, 2015)

  Anne Smits, Liesbeth Thewissen, Alexander Caicedo, Johan Nicolaï, Pieter Annaert, Gunnar Naulaers, Karel Allegaert
• OP 018: TO WHAT EXTENT DOES THE VANCOMYCIN ASSAY CONTRIBUTE TO THE VARIABILITY IN VANCOMYCIN CONCENTRATION ESTIMATES IN NEONATES? (14 December, 2015)

  J. Samardžić, A. Smits, V. Cossey, I. Soldatović, M. Bajčetić, J. N. van den Anker, K. Allegaert.
• OP 019: PHARMACOKINETIC STUDIES IN NEONATES: IS AN OPPORTUNISTIC SAMPLING STRATEGY SUFFICIENT FOR POPULATION PHARMACOKINETIC MODELLING AND DOSE PREDICTION? (14 December, 2015)

  Stéphanie Leroux, Mark A. Turner, Chantal Barin-Le Guellec, Helen Hill, Johannes N. van den Anker, Gregory L. Kearns, Evelyne Jacqz-Aigrain, Wei Zhao
• OP 020: EFFECT OF FLUSH VOLUME ON GENTAMICIN DELIVERY THROUGH UMBILICAL VENOUS CATHETERS (14 December, 2015)

  Anita Lala, David Reith, Roland Broadbent, Natalie Medilcott
• OP 021: PANTOPRAZOLE PHARMACOKINETICS IN OBESITY: WHERE GENES AND SIZE COLLIDE (14 December, 2015)

  Valentina Shakhnovich, Susan Abdel-Rahman, Craig Friesen, Robin Pearce, Andrea Gaedigk, J. Steven Leeder, Gregory Kearns
• OP 022: AUGMENTED RENAL CLEARANCE IMPLIES A NEED FOR INCREASED AMOXICILLIN-CLAVULANATE DOSING IN CRITICALLY ILL CHILDREN (14 December, 2015)

  Pieter De Cock, Joseph Standing, Charlotte Barker, Annick de Jaeger, Mieke Carlier, Evelyn Dhont, Alain Verstraete, Joris Delanghe, Hugo Robays, Peter De Paepe
• OP 023: POSSIBLE CONFOUNDERS IN THE REPORTED ASSOCIATION BETWEEN AUTISM SPECTRUM DISORDER (ASD) AND EXPOSURE TO SELECTIVE SEROTONIN REUPTAKE INHIBITORS (SSRIS) DURING PREGNANCY (14 December, 2015)

  Pauline De Bruyne, Eran Barzilay, Gideon Koren

POSTER PRESENTATIONS

• PP 024: A SYSTEMS PHARMACOLOGY MODEL TO EXPLAIN DEVELOPMENTAL DIFFERENCES IN SENSITIVITY TO DRUG-INDUCED QT PROLONGATION (14 December, 2015)

  Verena Gotta, Marc Pfister, John van den Anker, Piet van der Graaf
• PP 025: NEW ZEALAND FORMULARY FOR CHILDREN–A CASE STUDY OF NATIONAL PAEDIATRIC FORMULARY DEVELOPMENT (14 December, 2015)

  Bryan Simpson, David Reith, Natalie Medlicott, Alesha Smith, Murray Tilyard
• PP 026: NOVEL APP FOR SMARTPHONES AND TABLETS TO OPTIMIZE AND STANDARDIZE DRUG PRESCRIPTIONS IN NEONATES (14 December, 2015)

  Frederique Rodieux, Sachin Sanduja, Marc Pfister, John Van den Anker
• PP 027: NOVEL APP FOR PRACTICAL DOSING OF COMBINATION ANTIRETROVIRAL THERAPY IN PEDIATRIC PATIENTS WITH HIV/AIDS (14 December, 2015)

  J.N.Y. van den Anker, S. Sanduja, Kathleen Ferrer, N. Rakhmanina, Marc Pfister
• PP 028: SPONTANEOUS ADVERSE DRUG REACTION REPORTS FOR TRANSPLACENTAL AND TRANSMAMMARY ROUTES IN THOSE ≤1 YEAR IN THE UK 2001–2010 (14 December, 2015)

  Nicki-Jayne Russell, Mark Turner, Dan Hawcutt
• PP 029: NEONATAL ADVERSE DRUG REACTIONS: ANALYSIS OF PHARMACOVIGILANCE REPORTS AFTER DIRECT DRUG EXPOSURE IN FRANCE (14 December, 2015)

  Florentia Kaguelidou, Frédérique Beau-Salinas, Pascal Auriche, Evelyne Jacqz-Aigrain
• PP 030: SAFETY OF ACE INHIBITORS IN CHILDREN WITH HEART FAILURE (14 December, 2015)

  Marijke van der Meulen, Stephanie Läer, Cristina Castro, Feras Khalil, Saskia de Wildt, Michiel Dalinghaus, Ida Jovanović, Milica Bajčetić, Florian Lagler
• PP 031: JOINT COMMISSION INTERNATIONAL (JCI) IN THE PEDIATRIC INTENSIVE CARE UNIT (PICU): PREVENTING MEDICATION INCIDENTS THROUGH REMOTE CONTROL (14 December, 2015)

  Moran Lazaryan, Sofia Berkovitch, Michal Toledano, Noa Rosenfeld- Yehoshua, Ibraim Abu-Kishk, Matitiahu Berkovitch
• PP 032: MIDAZOLAM FOR IMAGING PROCEDURAL SEDATION IN CHILDREN: A SYSTEMATIC REVIEW (14 December, 2015)

  Badriyah Alotaibi, Imti Choonara, Helen Sammons
• PP 033: INDUSTRIAL ACTIVITY REVIEW OF THE FRENCH NETWORK OF PEDIATRIC CLINICAL INVESTIGATION CENTERS (FN-PCIC) 2008–2013 (14 December, 2015)

  Elsa Maksooud, Evelyne Jacqz-Aigrain
• PP 034: INNOVATIVE REGULATORY-CONFORMING BIOANALYTICAL APPROACHES ENABLING SYSTEMATIC INVESTIGATIONS OF PHARMACOKINETICS AND PHARMACODYNAMICS BY PAEDIATRIC CLINICAL STUDIES IN ALL AGE GROUPS (14 December, 2015)

  Björn B Burckhardt, Jutta Tins, Stephanie Läer
• PP 035: SAFE-PEDRUG: A NEW STRATEGY FOR PAEDIATRIC DRUG RESEARCH (14 December, 2015)

  Pauline De Bruyne, Kevin Meesters, Johan Vande Walle
• PP 036: SHORT-COURSE ORAL CORTICOSTEROID TOXICITY IN CHILDREN (14 December, 2015)

  Fahad Ajebab, Imti Choonara, Sharon Conroy
• PP 037: POPULATION PHARMACOKINETICS OF INTRAVENOUS ALBUTEROL IN CHILDREN WITH STATUS ASTHMATICUS (14 December, 2015)

  Nienke J Vet, Brenda CM de Winter, Saskia N de Wildt, Bart CH van der Nagel, Catherijne AJ Knibbe, Muriel Koninckx, Matthijs de Hoog, Birgit CP Koch
• PP 038: LEVOSIMENDAN IN TREATMENT OF CONGENITAL AND ACQUIRED HEART DISEASES (14 December, 2015)

  Senka Dinarević, Fedzat Jonuzi, Mirza Halimic, Zijo Begic, Almira Kadić, Refet Gojak
• PP 039: DRUG PRESCRIPTION PROFILE AND PERINATAL DETERMINANTS DURING THE FIRST YEAR OF LIFE (14 December, 2015)

  Daniele Piovani, Antonio Clavenna, Chiara Pavoni, Maurizio Bonati
• PP 040: GLATIRAMER ACETATE AND PREGNANCY IN WOMEN WITH MULTIPLE SCLEROSIS – RESULTS FROM THE GERMAN MULTIPLE SCLEROSIS AND PREGNANCY REGISTRY (14 December, 2015)

  Sandra Herbstritt, Ralf Gold, Kerstin Hellwig
• PP 041: ALPROSTADIL ASSOCIATED FEVER IN THE NEWBORN: SIDE EFFECT OR INFECTION? (14 December, 2015)

  Sohair Bshara Swaid, Amir Vardi, Amichai Perlman, Ilan Matok
• PP 042: THE CLINICAL UTILITY AND SAFETY OF A MODEL-BASED PATIENT-TAILORED DOSE REGIMEN OF VANCOMYCIN IN NEONATES (14 December, 2015)

  Stéphanie Leroux, Valérie Biran, Emmanuel Lopez, Doriane Madeleneau, Evelyne Jacqz-Aigrain, Wei Zhao
• PP 043: MAPPING IN VITRO AND IN VIVO DERIVED CYP2C9 AND CYP2C19 ONTOGENY FUNCTIONS: A CRITICAL COMPARISON BETWEEN VARIOUS ONTOGENY MODELS (14 December, 2015)

  Farzaneh Salem, Trevor Johnson, Amin Rostami-Hodjegan
• PP 044: IMPLEMENTATION OF CLONIDINE AS A NEW SEDATIVE AND ANALGESIC DRUG IN THE NICU–A RETROSPECTIVE REPORT ON MEDICAL RECORDS (14 December, 2015)

  Charlotte Ragnarsson, Elisabeth Norman
• PP 045: PROSPECTIVE VALIDATION OF A MODEL-BASED DOSING REGIMEN FOR AMIKACIN IN NEONATES: FEASIBLE AND RELEVANT (14 December, 2015)

  Anne Smits, Roosmarijn De Cock, Karel Allegaert, Sophie Vanhaesebrouck, Meindert Danhof, Catherijne Knibbe
• PP 046: POPULATION PHARMACOKINETICS AND DOSING OPTIMIZATION OF TEICOPLANIN IN CHILDREN WITH MALIGNANT HAEMATOLOGICAL DISEASE (14 December, 2015)

  Wei Zhao, Daolun Zhang, Thomas Storme, André Baruchel, Xavier Declèves, Evelyne Jacqz-Aigrain
• PP 047: ANTIEPILEPTIC DRUG PRESCRIBING FOR CHILDREN IN ITALY (14 December, 2015)

  Daria Putignano, Antonio Clavenna, Rita Campi, Maurizio Bonati
• PP 048: SPONTANEOUS ADVERSE DRUG REACTION REPORTS FOR NEONATES AND INFANTS IN THE UK 2001–2010 (14 December, 2015)

  Dan Hawcutt, Hannah Maqsood, Simon Gomberg, Andrew Riordan, Mark Turner
• PP 049: RISK FACTORS FOR NODAT UNDER IMMUNOSSUPPRESSANTS IN RENAL TRANSPLANTED CHILDREN (14 December, 2015)

  Pauline Lancia, Wei Zhao, Anne Maisin, Dominique Simon, Veronique Elie, Valery Elie, Evelyne Jacqz-Aigrain
• PP 050: PARACETAMOL DISPOSITION IN YOUNG WOMEN: BOTH PREGNANCY AND TOOLS TO AVOID PREGNANCY MATTER (14 December, 2015)

  Karel Allegaert, Mariska Y Peeters, Bjorn Beleyn, Anne Smits, Aida Kulo, Kristel van Calsteren, Jan Deprest, Catherijne AJ Knibbe
• PP 051: PULMONARY HYPERTENSION IN PAEDIATRIC PATIENTS: DATA FROM THE COMPERA-KIDS REGISTRY (14 December, 2015)

  Matthias Gorenflo, David Pittrow, Dörte Huscher, Victoria Ziesenitz, Joseph Pattathu, Alexander Praus, Peter Ewert, Harald Kaemmerer, COMPERA-Kids Steering Committee Study Group
• PP 052: ACUTE POISONINGS IN A CHILDREN'S EMERGENCY DEPARTMENT (14 December, 2015)

  Elizabeth Starkey, Helen Sammons
• PP 053: RISKS IN PHARMACOLOGICAL TREATMENT OF PEDIATRIC INPATIENTS–THE DOCTORś AND NURSEŚ VIEWS (14 December, 2015)

  Lina Lilja, Christiane Garnemark, Jenny Kindblom
• PP 054: UNINTENTIONAL OVERDOSING OF INTRAVENOUS PARACETAMOL IN NEONATES: WHERE IS THE TOXICITY? (14 December, 2015)

  Barbara Bosch, Kristina Casteels, Karel Allegaert
• PP 055: DO WE HAVE A CONSENSUS TO APPLY MODEL-BASED AMINOGLYCOSIDE THERAPY: A REVIEW OF POPULATION PHARMACOKINETIC MODELS (14 December, 2015)

  Guo-Xiang Hao, Sophie Teng, Evelyne Jacqz-Aigrain, Wei Zhao
• PP 056: EXTENDED INTERVAL GENTAMICIN DOSING IN PRETERM INFANTS LESS THAN 35 WEEKS CORRECTED GESTATIONAL AGE (14 December, 2015)

  Jarrid W R McKitrick, Brad Bewick, Robert Ariano, Sheryl Zelenitsky, Michael Narvey, Geert W 't Jong
• PP 057: SEASONAL VARIATIONS IN ANTIBIOTIC CONSUMPTION IN PAEDIATRIC PRIMARY CARE SETTINGS IN SERBIA (14 December, 2015)

  Bojana Božić, Milica Bajčetić
• PP 058: FLUOROQUINOLONES IN PEDIATRIC PATIENTS: NO MORE “OFF-LABEL USE” (14 December, 2015)

  Natalie Dinavitser, Maya Berlin, Reuven Miller, Victoriya Finkel-Pekarsky, Matitiahu Berkovitch
• PP 059: EXTREMELY PREMATURE NEONATES EXHIBIT INSULIN RESISTANCE (14 December, 2015)

  Emma R Salis, David M Reith, Roland S Broadbent, Benjamin J Wheeler, Natalie J Medlicott
• PP 060: LEGAL RESPONSIBILITY PRESCRIBING OFF-LABEL DRUGS: IS SPAIN DIFFERENT? (14 December, 2015)

  Maria A. Peire
• PP 061: HOW SAFE IS ON-LABEL DRUG USE IN PAEDIATRICS? THE CASE OF FIRST GENERATION H1-ANTIHISTAMINES (14 December, 2015)

  Pauline De Bruyne, Koen Boussery, Thierry Christiaens, Els Mehuys, Myriam Van Winckel
• PP 062: USE OF FLUOROQUINOLONES IN HOSPITALIZED CHILDEN, PRELIMINARY REPORT OF A CHART REVIEW IN A BELGIAN UNIVERSITY CHILDREN'S HOSPITAL (14 December, 2015)

  Kevin Meesters, Pauline De Bruyne, Reiner Mauel, Johan Vande Walle
• PP 063: EVALUATION OF A PEDIATRIC LIQUID FORMULATION TO IMPROVE 6-MERCAPTOPURINE THERAPY IN CHILDREN (14 December, 2015)

  Tiphanie Adam de Beaumanis, Lisa Lynqsie Hjalgrim, Jacob Nersting, Jörg Breitkreutz, Yves Bertrand, Martin Stanulla, Guy Leverger, André Baruchel, Kjeld Schmiegelow, Evelyne Jacqz-Aigrain
• PP 064: SLOW INFUSIONS OF GENTAMICIN ARE ASSOCIATED WITH HIGH VARIABILITY IN PEAK GENTAMICIN CONCENTRATIONS IN LOW GESTATION AGE (GA) NEONATES (14 December, 2015)

  Natalie Medlicott, Louise Thomas, Roland Broadbent, David Reith
• PP 065: GENTAMICIN PHARMACOKINETIC VARIABILITY IS INFLUENCED BY CHOICE OF ADMINISTRATION ROUTE (14 December, 2015)

  Anita Lala, Natalie Medlicot, Roland Broadbent, Frances McCaffrey, David Reith
• PP 066: A BLUE-PRINT FOR PERFORMING PAEDIATRIC PHARMACOLOGICAL RESEARCH (14 December, 2015)

  Eric Vermeulen, Debbie Nuytemans, Timo de Haan, Robert Flint, Johanna van der Lee
• PP 067: DESIGN OF A EUROPEAN SURVEY ON THE PHARMACOLOGICAL MANAGEMENT OF PAEDIATRIC HEART FAILURE (14 December, 2015)

  Cristina Castro Díez, Feras Khalil, Michiel Dalinghaus, Marijke van der Meulen, Saskia de Wildt, Ida Jovanović, Milica Bajčetić, Michel Burch, Christoph Male, Stephanie Läer
• PP 068: AVAILABILITY OF PAEDIATRIC-EVALUATED FORMULATIONS IN SERBIA (14 December, 2015)

  Bojana Božić, Sanja Stupar, Duško Stupar, Milica Bajčetić
• PP 069: RANDOMISED CONTROLLED TRIALS OF CHRONIC PAIN IN CHILDREN AND ADOLESCENTS: A SYSTEMATIC REVIEW (14 December, 2015)

  Rym Boulkedid, Armiya Yousouf Abdou, Emilie Desselas, Marlène Monegat, Corinne Alberti, Florentia Kaguelidou
• PP 070: SAFETY OF LAMOTRIGINE IN PAEDIATRICS: A SYSTEMIC REVIEW (14 December, 2015)

  Oluwaseun Egunsola, Imti Choonara, Helen Sammons
• PP 071: EVALUATION OF THE APPLICABILITY OF A CHILD-APPROPRIATE HIGH THROUGHPUT HPLC-MS/MS METHOD FOR THE DETERMINATION OF ENALAPRIL AND ENALAPRILAT IN SMALL SAMPLE VOLUMES OF SERUM AND URINE WITHIN A GCLP-COMPLIANT ENVIRONMENT (14 December, 2015)

  Julia Schäfer, Björn B. Burckhardt, Jutta Tins, Stephanie Läer
• PP 072: DEVELOPMENT AND ESTABLISHMENT OF A QUALITY-FRAMEWORK FOR THE LENA PROJECT (14 December, 2015)

  Agnes M. Ciplea, Karl Kleine, Björn B. Burckhardt, Stephanie Läer, Jörg Breitkreutz, Lucie Špatenková, Ingrid Klingmann
• AUTHOR INDEX (14 December, 2015)