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Optimal management of polycystic ovary syndrome in adolescence
  1. Natalie Hecht Baldauff1,
  2. Silva Arslanian1,2
  1. 1Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, USA
  2. 2Division of Weight Management and Wellness, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, USA
  1. Correspondence to Dr Natalie Hecht Baldauff, Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children's Hospital of Pittsburgh of UPMC, 8th Floor Faculty Pavilion, 4401 Penn Avenue, Pittsburgh, PA 15224, USA; natalie.baldauff{at}chp.edu

Abstract

Polycystic ovary syndrome (PCOS) is a heterogeneous disorder of reproduction and metabolism, which emerges at puberty, and is characterised by a wide spectrum of signs and symptoms of hyperandrogenism, anovulation, hyperinsulinaemia and associated comorbidities. Unlike adult PCOS, there are no agreed-upon diagnostic criteria for adolescent PCOS, but hyperandrogenaemia remains the sine qua non for its diagnosis. Many adolescent girls with PCOS are overweight/obese, and have a heightened risk for comorbidities such as dysglycaemia, dyslipidaemia, fatty liver disease, sleep apnoea and cardiovascular disease. Therefore, early and accurate diagnosis is essential for implementation of appropriate treatment and management. Available treatments include lifestyle modifications, hormonal contraceptives and insulin sensitisers. However, there are limited data on the best treatment modalities in adolescents. The objective of this review is to describe the clinical manifestations of PCOS in adolescents and the appropriate diagnostic work-up. The optimal treatment modalities based on a review of the available adult and adolescent literature will be discussed.

  • Adolescent Health
  • Endocrinology
  • Metabolic
  • Obesity

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