Methodology
Lung deposition of aerosol
a comparison of different spacers
H J Zar, E G Weinberg, H J Binns, F Gallie, M D Mann
Department of
Paediatrics and Child Health, Red Cross War Memorial Children's
Hospital, University of Cape Town, Cape Town, South Africa
Correspondence to: Dr H Zar, Child Health Unit, 46 Sawkins Road, Rondebosch, 7700, South Africa email: heather{at}rmh.uct.ac.za
Accepted 4 February
2000
AIMS
To investigate (1) aerosol
lung deposition obtained from two small volume conventional spacers
(Babyhaler and Aerochamber) and a home made spacer (modified 500 ml
plastic cold drink bottle); (2) the effect of using a face mask or
mouthpiece; and (3) the relation between age and pulmonary deposition.
METHODSLung deposition of
aerosolised technetium-99m DTPA inhaled via spacer was measured in 40 children aged 3-7 years with stable asthma. Each patient performed
sequential randomly assigned inhalations using two spacers. Three
studies were performed: Babyhaler compared to Aerochamber (with
facemasks); Babyhaler with facemask compared to Babyhaler with
mouthpiece; and Babyhaler with mouthpiece compared to a 500 ml bottle.
RESULTSMedian lung aerosol
deposition from a Babyhaler and Aerochamber with masks were similar
(25% v 21%, p = 0.9). Aerosol lung deposition from a Babyhaler with mask compared to a Babyhaler with
mouthpiece was equivalent (26% v 26%,
p = 0.5). Lung deposition was higher from a 500 ml bottle compared to
a Babyhaler in both young (25% v 12.5%,
p = 0.005) and older children (42% v
22.5%, p = 0.003). A notable reduction in pulmonary deposition
occurred at 50 months of age.
CONCLUSIONA Babyhaler or
Aerochamber produce equivalent lung deposition of aerosol. There is no
difference in lung deposition when a mask or mouthpiece is used. A
modified 500 ml plastic bottle produces greater pulmonary aerosol
deposition than a conventional small volume spacer.
Keywords: spacer; pulmonary aerosol deposition
© 2000 by Archives of Disease in Childhood
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Arch. Dis. Child. 2000 82: 0.[Extract] [Full Text]
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eLetters:
Read all eLetters
- Should use of home-made spacers be incorporated into guidelines for asthma management?
- SK Agarwal
- ADC Online, 28 Jun 2000 [Full text]
- Spacers and holding chambers: Not the last word, we hope
- Jolyon P Mitchell
- ADC Online, 31 Jul 2000 [Full text]
- Re: Spacers and holding chambers: Not the last word, we hope
- Heather Zar
- ADC Online, 3 Aug 2000 [Full text]
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