Archives of Disease in Childhood 2008;93:182-183
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Idiopathic thrombocytopenic purpura and the second dose of MMR
1 Immunisation Department, Health Protection Agency Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, UK
2 Statistics, Modelling and Bioinformatics Department, Health Protection Agency Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, UK
Professor Elizabeth Miller, Immunisation Department, Health Protection Agency Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, UK; liz.miller@hpa.org.uk
| The first 150 words of the full text of this article appear below. |
An increase in idiopathic thrombocytopenic purpura (ITP) cases in the 6 weeks following the first dose of the measles, mumps and rubella (MMR) vaccine has been established, with absolute risks estimated as 1 in 22 3001 and 1 in 21 000 vaccine doses,2 with two in every three cases attributable to the vaccine. However, the risk after a second dose of MMR vaccine has not been investigated.
Hospital admissions for children aged from 3 to <6 years with a discharge diagnosis of ITP (ICD-code D693 in any diagnosis field) were identified from computerised hospital episode data from North, East and South London, Essex, East Anglia, Sussex and Kent for the period from 1 April 1997 to 31 December 2005. These admissions were then linked to second MMR dose records held on population-based child-health database systems. Only successfully linked admissions were used for the analysis.
A re-admission for ITP within 10 days
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