ADC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH REGISTER


[Advanced]
The most recent version of this article was published on 1 January 2008

Arch Dis Child. Published Online First: 4 October 2007. doi:10.1136/adc.2007.120675
Copyright © 2007 BMJ Publishing Group Ltd & Royal College of Paediatrics and Child Health
This Article
Right arrow Full Text (Rapid PDF)
Right arrow All Versions of this Article:
adc.2007.120675v1
93/1/30    most recent
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this link to a friend
Right arrow Similar articles in ADC Online
Right arrow Similar articles in PubMed
Right arrow Add article to my folders
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Aksglaede, L.
Right arrow Articles by Juul, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Aksglaede, L.
Right arrow Articles by Juul, A.

Original articles

Normal bone mineral content but unfavourable muscle/fat-ratio in Klinefelter syndrome

Lise Aksglaede 1*, Christian Molgaard 2, Niels E Skakkebæk 3 and Anders Juul 3

1 University of Copenhagen, Rigshospitalet, Dep. of Growht and Reproduction, Denmark
2 University of Copenhagen, Faculty of Life Sciences and Rigshospitaet, Dep. of Human Nutrition, Denmark
3 University of Copenhagen, Rigshospitalet, Dep. of Growth and Reproduction, Denmark

* To whom correspondence should be addressed. E-mail: lise.aksglaede{at}rh.hosp.dk.

Accepted 22 September 2007


*   Abstract

Objective: To evaluate body composition and bone mineral content (BMC) in children and adolescents with Klinefelter syndrome.

Design: Retrospective cross-sectional study.

Setting: Tertiary endocrine clinic at the University Hospital, Copenhagen.

Patients: Eighteen untreated and six androgen-substituted boys with KS aged 11.0 years (range 4.3 to 18.6) participated.

Intervention: Dual energy X-ray absorptiometry and anthropometric measurements were analysed. Main Outcome Measures: Lumbar and whole body BMC, lean body mass (LBM), body fat mass (BFM), body fat percentage (BF%), height and body mass index (BMI) were compared between treated and untreated KS boys and compared to normal age-matched boys.

Results: LBM (untreated -0.3 (-2.4 to +2.1) and treated +1.1 (-1.6 to +2.1)) was normal while BFM (untreated +0.5 (-1.0 to +2.3), p=0.02 and treated +1.6 (-0.2 to +2.4), p=0.01) was significantly increased, all expressed as SDS. Lumbar BMD (untreated -0.4 (-3.1 to +0.9) and treated +1.0 (-1.4 to +3.0)) and whole body BMC (untreated +0.1 (-1.8 to +3.3) and treated +1.5 (-1.1 to +2.5)) was normal.

Conclusion: We found significantly increased BFM and BF% despite normal LBM, suggesting the presence of an unfavourable muscle/fat ratio. Lumbar BMD and whole body BMC were normal. These findings suggest that the unfavourable metabolic profile seen in adult KS may already be present in childhood as evidenced by the increased fat mass, whereas the reported low BMD seems to develop after puberty.

Keywords: Body fat mass, Bone mineral content, Klinefelter syndrome






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH REGISTER
ARCH DIS CHILD FETAL NEONATAL ED ED PRACTICE
Terms and conditions relating to subscriptions purchased online  ¦  Website terms and conditions  ¦  Privacy policy
Copyright © 2007 BMJ Publishing Group Ltd & Royal College of Paediatrics and Child Health