Arch Dis Child. Published Online First: 4 May 2005. doi:10.1136/adc.2005.075333
Original articles |
Risk of hypertension with multicystic kidney disease: A systematic review
1 Sandwell General Hospital, United Kingdom
* To whom correspondence should be addressed. E-mail: hassibnarchi{at}hotmail.com.
Accepted 1 May 2005
Abstract
Objective:Children with multicystic kidney disease (MCKD) are increasingly managed conservatively and are followed up throughout childhood because of the risk of hypertension highlighted in some reports. With this risk still poorly defined, the strategy and the duration of follow up do not seem to be based on evidence.
Design and methods:Systematic review of the literature for all published cohort studies (prospective and retrospective) of children diagnosed to have unilateral MCKD and managed conservatively. Exclusion criteria: bilateral MCKD, nephrectomy (not for hypertension) during the follow up period. We estimated for children with MCKD the probability of developing hypertension during the follow up period, with 95% confidence intervals (95% ci)using the Poisson distribution.
Results:From 29 reviewed studies, 6 cases of hypertension developed in 1115 eligible children. The mean probability of a child with unilateral MCKD to develop hypertension was therefore 5.4 per 1000 ( 95% confidence intervals estimated at 1.9 and 11,7 per 1,000)
ConclusionAlthough the risk of hypertension in MCDK is low, the results of this study do not allow firm recommendations on the frequency and duration of blood pressure measurements follow up for these children. Large prospective cohort studies with a very long duration of follow up are needed.
Keywords: Hypertension, Kidney Diseases, Multicystic Dysplastic Kidney
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- Risk of hypertension in children with multicystic dysplastic kidney
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- ADC Online, 17 Oct 2005 [Full text]
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- ADC Online, 24 Oct 2005 [Full text]
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