HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER		Author Keyword(s) Vol Page [Advanced]

This Article Full Text Full Text (PDF) All Versions of this Article: adc.2005.091231v1 93/1/45    most recent Submit a response Read responses to this article Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this link to a friend Similar articles in ADC Online Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Thia, L. P Articles by Carr, S. B Search for Related Content PubMed PubMed Citation Articles by Thia, L. P Articles by Carr, S. B

Randomised controlled trial of nasal continuous positive airways pressure (CPAP) in bronchiolitis

Department of Paediatric Respiratory Medicine, Royal London Hospital, London, UK

Correspondence to:
Lena P Thia, Department of Paediatric Respiratory Medicine, Royal London Hospital, Whitechapel Road, London, UK; lthia{at}doctors.org.uk

Aims: To compare continuous positive airways pressure (CPAP) with standard treatment (ST) in the management of bronchiolitis.

Methods: Children <1 year of age with bronchiolitis and capillary PCO₂ >6 kPa were recruited and randomised to CPAP or ST and then crossed over to the alternative treatment after 12 h. ST was intravenous fluids and supplemental oxygen by nasal prongs or face mask. The change in PCO₂ was compared between the groups after 12 and 24 h. Secondary outcomes were change in capillary pH, respiratory rate, pulse rate and the need for invasive ventilatory support.

Results: 29 of 31 children completed the study. PCO₂ after 12 h fell by 0.92 kPa in children treated with CPAP compared with a rise of 0.04 kPa in those on ST (p<0.015). If CPAP was used first, there was a significantly better reduction in PCO₂ than if it was used second. There were no differences in secondary outcome measures. CPAP was well tolerated with no complications identified.

Conclusions: This study suggests that CPAP compared with ST improves ventilation in children with bronchiolitis and hypercapnoea.

This article has been cited by other articles:

				R K Philip Power of numbers versus number of powers Arch. Dis. Child., July 1, 2008; 93(7): 637 - 638. [Full Text] [PDF]

				F. Martinon-Torres, A. Rodriguez-Nunez, and J. M. Martinon-Sanchez Nasal Continuous Positive Airway Pressure With Heliox Versus Air Oxygen in Infants With Acute Bronchiolitis: A Crossover Study Pediatrics, May 1, 2008; 121(5): e1190 - e1195. [Abstract] [Full Text] [PDF]

eLetters: