Letters to the editor
Allicin: a possible answer to antibiotic resistant campylobacter diarrhoeal infection?
| The first 150 words of the full text of this article appear below. |
EDITOR,
Several Campylobacter
spp are a frequent cause of gastroenteritis in children,
particularly those younger than 2 years in developing
countries.1 Recent articles have reported the emergence of
campylobacter isolates resistant to quinolones, which are commonly used
for the treatment of this infection.2 We have observed the
emergence of Campylobacter spp resistant to nalidixic acid, a commonly used quinolone. We propose that due consideration be given to the research and development of allicin, the
primary antimicrobial component in garlic (Allium
sativum) as an alternative form of enteral treatment in cases of
campylobacter infection that fail to respond to conventional antibiotic
regimens. Allicin, a naturally occurring antibiotic, has been shown in
vitro to have a broad spectrum of activity against Gram positive and Gram negative bacteria, yeasts,3
Candida spp,
Cryptococcus neoformans, and
Helicobacter pylori.4
The antibacterial effect of an aqueous garlic extract was investigated
against 38 clinical
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