MISCELLANEA
Paracetamol and atopic diseases
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Evidence has accumulated over the last few years that the use of paracetamol during pregnancy, in childhood and as an adult may increase the risk of asthma. Phase three of the International Study of Asthma and Allergies in Childhood (ISAAC) has provided more data (Richard Beasley and colleagues. The Lancet 2008;372:1039–48; see also Comment, ibid: 1011–12).
The study included 205 487 children aged 6–7 years at 73 centres in 31 countries on six continents. Information was collected from parents or guardians by questionnaire. Around the world, most children were given paracetamol in infancy. Multivariate analysis of data from 105 041 children with covariate data showed that paracetamol use for fever in infancy increased the risk of asthma symptoms, rhinoconjunctivitis and eczema at age 6–7 years by 46%, 48% and 35%, respectively. The increased risk of asthma symptoms varied from 22% in the Indian subcontinent to 82% in the
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