Archives of Disease in Childhood 2008;93:444-445
Archimedes
Question 2
SHOULD GONADOTROPIN RELEASING HORMONE ANALOGUE BE ADMINISTERED TO PREVENT PREMATURE OVARIAN FAILURE IN YOUNG WOMEN WITH SYSTEMIC LUPUS ERYTHEMATOSUS ON CYCLOPHOSPHAMIDE THERAPY?
Paediatric Nephrology, British Columbia’s Children’s Hospital, Vancouver, BC, Canada; rajivsinha_in@yahoo.com
Paediatric Nephrology, British Columbia’s Children’s Hospital, Vancouver, BC, Canada
| The first 150 words of the full text of this article appear below. |
A 15-year-old girl with acute renal failure was found to have class IV systemic lupus erythematosus (SLE) nephritis on renal biopsy. A decision was taken to start her on the routine National Institute of Health protocol of pulsed methyl-prednisolone and monthly intravenous cyclophosphamide (CYC) (0.5–1.0 g/m2 of body surface area). With her post-pubertal status and the possibility of CYC induced gonadal toxicity, the question was raised as to whether she should be put on gonadotropin releasing hormone analogue (GnRH-a) therapy for ovarian protection.
In young female patients with SLE undergoing CYC therapy [patient], does the use of GnRH-a [intervention], when compared to no intervention [comparison], prevent premature ovarian failure [outcome]?
[Lupus or Systemic lupus erythematosus] AND [cyclophosphamide] AND [gonadal toxicity or premature ovarian failure or fertility] AND [gonadotropin releasing hormone analogue or GnRH or GnRH-a] Limits: English, Human
Cochrane Library: None relevant
Medline: 1950–to date; EMBASE: 1974–to date;
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