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Is scoliosis an issue for giving growth hormone to children with Prader–Willi syndrome?
1 Centre de Référence du syndrome de Prader-Willi, Department of Endocrinology, Genetics, Gynaecology and Bone Diseases, Hôpital des Enfants, CHU Toulouse, France
2 Department of Orthopedic Surgery, Hôpital des Enfants, CHU Toulouse, France
Correspondence to:
Professor M Tauber, Centre de Référence du syndrome de Prader-Willi, Department of Endocrinology, Genetics, Gynaecology and Bone Diseases, Hôpital des Enfants, 330 avenue de Grande Bretagne, CHU Toulouse 31059, France; tauber.mt@chu-toulouse.fr
| The first 150 words of the full text of this article appear below. |
Prader–Willi syndrome (PWS) is a rare genetic disorder with a large range of severe co-morbidities including severe neonatal hypotonia with failure to thrive and dysmorphic features during the first months of life followed by the development of morbid obesity and endocrine disorders related to hypothalamic dysfunction (growth hormone (GH) deficiency, hypogonadism, oxytocin deficiency) associated with learning disabilities and behavioural and psychiatric problems.1 2 Early diagnosis combined with multidisciplinary care, parental guidance and GH treatment prevent precocious and morbid obesity in most cases.3
Since optimisation of the management of obesity and other endocrine disorders in these children, experts now have to deal with other pathological conditions that were less often reported when morbid obesity was the biggest challenge. Indeed, management of psychiatric disorders and other co-morbidities of this highly complex disease, such as scoliosis, requires specific attention. These "new" issues appear as a result of improved knowledge of the natural history of
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