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Allergy, immunology and infection

G/THUR/ALL1 FIRST HEAD-TO-HEAD COMPARISON OF SKIN TESTING AND INTERFERON-GAMMA RELEASE ASSAYS IN CHILDREN WITH ACTIVE AND LATENT TUBERCULOSIS IN THE UK
S. Anderson², S. Walters¹, B. Williams², A. Williams², A. Gordon¹, N. Martinez-Alier¹, B. Kampmann¹.¹Imperial College, London, UK; ²Northwick Park NHS Trust, London, UK

Background: Many believe that the tuberculin-skin-test (TST) is a blunt tool for diagnosing MTB infection in children. The new NICE Guidelines for tuberculosis recommend the use of IFNGRA in TST positive children. However, there is no guidance on which assay to use and there is a paucity of data regarding the performance of these assays in children. No direct comparison between all 3 available tests for the diagnosis of childhood Tb (active or latent) in UK cohorts has been published.

Aims: To assess the performance of TST and IFNGRA in a UK paediatric cohort.

Methods: Side-by-side comparison of the two commercially available IFNGRA (T-SpotTB and Quantiferon Gold QFG) and the TST in children referred to our paediatric TB clinics . . . [Full text of this article]