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Perinatal medicine

G/TUES/PER1 EVOLUTION OF LUNG FUNCTION ABNORMALITIES IN INFANTS DEVELOPING MILD OR MODERATE/SEVERE BRONCHOPULMONARY DYSPLASIA
C. May, C. Kennedy, G. Rafferty, A. Greenough.Division of Asthma, Allergy and Lung Biology, King’s College London, London, UK

Background: Nowadays, very prematurely born infants, who are chronically oxygen dependent, may have a maldevelopment sequence resulting from interference/interruption of normal developmental signalling for terminal maturation and alveolarisation of the lungs rather than the injury/repair paradigm of traditional BPD.¹ How this affects their lung function and whether the severity of BPD influences any lung function abnormalities remain to be determined.

Objective: To test the hypothesis that particularly infants with moderate/severe BPD will have low lung volumes throughout the neonatal period reflecting abnormal antenatal lung growth.

Methods: Serial lung function measurements (compliance (CRS) and resistance (RRS) of the respiratory system by single breath mechanics and lung volume assessed by measurement of functional residual capacity (FRC) using a helium gas dilution technique) were attempted on days 3, 5, 7, 14, 21 and . . . [Full text of this article]