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International child health

G/TUES/INT1 VOLUME EXPANSION WITH ALBUMIN COMPARED TO GELOFUSINE IN CHILDREN WITH SEVERE MALARIA: RESULTS OF A CONTROLLED TRIAL
S. Akech¹, S. Gwer¹, R. Idro¹, G. Fegan², A. Eziefula¹, C. Newton³, M. Levin⁴, K. Maitland⁴.¹Centre for Geographic Medicine Research (coast), Kenya Medical Research Institute (KEMRI), Kilifi, Kenya; ²Infectious Diseases Epidemiology Unit, London School of Hygiene and Tropical Medicine, London, UK; ³Neurosciences Unit, Institute of Child Health, The Wolfson Centre, Mecklenburgh Square, London, UK; ⁴Department of Paediatrics and Wellcome Trust Centre for Clinical Tropical Medicine, Faculty of Medicine, Imperial College, Norfolk Place, London, UK

Aims: Previous studies have shown that resuscitation with albumin infusion resulted in a lower mortality than saline in severe malaria. Whether the apparent benefit of albumin is due solely to its colloidal properties, and thus might also be achieved with other synthetic colloids, or due to the many other unique physiological properties of albumin is unknown. As albumin is costly and not readily available in Africa examination . . . [Full text of this article]