PERSPECTIVES
Neonatal epilepsy
Treatable neonatal epilepsy
1 Neurosciences Unit, UCL Institute of Child Health, London, UK
2 Department of Paediatric Neurology, University Children’s Hospital, Heidelberg, Germany
Correspondence to:
Correspondence to:
Professor Surtees
The Wolfson Centre, Mecklenburgh Square, London WC1N 2AP, UK; R.Surtees@ich.ucl.ac.uk
Perspective on the paper by Bok et al (see 687)
| The first 150 words of the full text of this article appear below. |
Treatable metabolic causes of early onset epilepsy (in the first few months of life) are uncommon but it is important to diagnose them because delay in specific treatment commonly results in poor neurological and cognitive outcome. Indeed, some of these epilepsies are fatal if left untreated. The disorders are listed in table 1
and are divided into vitamin-responsive and other metabolic epilepsies.
|
View this table: Table 1 Treatable metabolic causes of early onset epilepsy |
We are not going to discuss all of these disorders, but will confine ourselves to those presenting at or very close to birth. The investigation and treatment of the other epilepsies are summarised in table 2.
|
View this table: Table 2 Investigation and treatment of metabolic causes of early onset epilepsy |
Typical neonatal onset pyridoxine-dependent epilepsy (PDE) presents in the first few days of life with multiple seizure types which are intractable to anticonvulsant drug treatment. Experienced mothers may also recognise seizures in
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