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Should creatine kinase be checked in all boys presenting with speech delay?

Edited by Bob Phillips

¹ Department of Paediatric Neurology, Paul Ward, Royal Belfast Hospital for Sick Children, 180 Falls Road, Belfast BT12 6BE, UK; clairelundy@btopenworld.com
² Royal Belfast Hospital for Sick Children, Belfast, UK

The first 150 words of the full text of this article appear below.

Jack is a 2.5 year old boy. He has been referred for developmental assessment by his health visitor. His community paediatrician diagnoses speech and language delay. His mother reports he first sat independently at 9 months and walked at 17 months.

Structured clinical question
In a male child with speech delay who walks prior to 18 months old [patient], does requesting serum creatine kinase [intervention] help diagnose Duchenne muscular dystrophy with reasonable efficiency [outcome]?

Search strategy and outcome
PubMed: "Duchenne muscular dystrophy," "speech delay", combined with "screening" and "language". Sixteen references were found in total.

OMIM database and specific journals: The titles and the abstracts were reviewed. Eleven studies were relevant; seven articles were selected as directly related to the question.

Searches were carried out in August 2006.

See table 3.