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Is the topical application of oestrogen cream an effective intervention in girls suffering from labial adhesions?

Edited by Bob Phillips

¹ Department of Paediatrics, Southend University Hospital, Southend-on-Sea, UK; marctebruegge@nhs.net
² Department of Paediatrics, Southend University Hospital, Southend-on-Sea, UK

The first 150 words of the full text of this article appear below.

A 4-year-old girl presents with low-grade pyrexia and dysuria. A urine dipstick test shows positive results for leucocytes and nitrite, suggesting urinary tract infection. On examination, you notice partial adherence of the vulval labia minora. Her mother reports that the girl has intermittently had discomfort in the genital area over the last year. While waiting for the results of the urine microscopy, you remember that one of your colleagues has mentioned treating labial adhesions with oestrogen creams in the past. You wonder whether there is good evidence to support their use in this condition.

Structured clinical question
In a girl with labial adhesions (patient), is oestrogen cream (intervention) an effective treatment to induce labial separation (outcome)?

Search strategy and outcome
Cochrane Library using the terms "labial adhesion AND treatment", "labial adhesion AND management" and "labial adhesion and oestrogen/estrogen" as well as three alternative terms for labial adhesion ("labial fusion", "labial agglutination", "synechia vulvae") . . . [Full text of this article]