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Radiological findings in cyclical administration of intravenous pamidronate in children with osteoporosis

Children’s University Hospital, Temple Street, Dublin, Ireland

Correspondence to:
C Onwuneme, Children’s University Hospital, Temple Street, Dublin 1, Ireland; drchike2001@yahoo.com

The first 150 words of the full text of this article appear below.

A 5-year-old boy with moderately severe osteogenesis imperfecta and spontaneous fractures was treated with serial courses of intravenous pamidronate. Pamidronate is a second-generation bisphosphonate drug that binds strongly to bone mineral and interferes with bone remodelling by slowing osteoclastic bone resorption. It is used in a cyclic dosage of 1 mg/kg/day intravenously on 3 successive days at 4-monthly intervals. A radiograph of the knee after treatment showed a pattern of parallel dense metaphyseal lines (fig 1A).

View larger version (108K):   Figure 1 (A) A 5-year-old boy with osteogenesis imperfecta after cyclic treatment with biphosphonates. AP radiograph of the knee shows dense parallel bands in distal femoral and proximal tibial and fibular metaphyses. (B) A 16-year-old boy with camptodactyly coxavara arthropathy pericarditis syndrome (C-CAP syndrome) and osteoporosis who had cyclic treatment with biphosphonates. AP radiograph of the knee shows dense parallel bands in distal femoral and proximal tibial and fibular metaphyses. Lines are closer to . . . [Full text of this article]