Archives of Disease in Childhood 2007;92:1055-1057
Leading articles
MMR
MMR: where are we now?
1 Islington PCT and Great Ormond Street Hospital for Children, Great Ormond Street, London, UK
2 Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London, UK
David Elliman, Great Ormond Street Hospital for Children, Great Ormond Street, London WC1N 3JH, UK; ellimd@gosh.nhs.uk
Accepted 12 June 2007
There is no scientific evidence of a link between bowel disease and/or autism and MMR vaccine. Attainment of a high uptake of the vaccine should be encouraged.
| The first 150 words of the full text of this article appear below. |
The combined measles, mumps and rubella (MMR) vaccine was introduced to the UK in 1988 and uptake of the vaccine rose rapidly to a high of 92%. In 1992, brands containing the Urabe strain of the mumps vaccine virus were withdrawn after it was noted to be associated with an increased risk of aseptic meningitis.1 This did not appear to have a deleterious effect on uptake. In 1995, a paper was published suggesting a link between measles vaccines and the development of bowel disorders in adulthood.2 This was associated with a small decline in the uptake of MMR vaccine. In 1998, the same group of researchers published observations of 12 children with pervasive developmental disorders and bowel disease and suggested that the latter may have led to the former.3 In eight children, the history of the onset of symptoms coincided with receipt of MMR vaccine. Although the researchers stated
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