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Immunisations have changed dramatically over the past decade. Virtually every year new vaccinations are introduced, old ones modified and new combinations created. This past year has seen the worldwide introduction of vaccines for human papillomavirus and rotavirus. New delivery systems are being developed, including additional intranasal and oral preparations, immunisations that need no cold storage, and systems so radically different, such as incorporating immunisations into common foods or on plants, that virtually entire populations could be vaccinated quickly and cheaply. Finally, neonatal immunisation that could trigger life long memory is under investigation. Numerous issues continue to be debated. How safe are vaccines? In this issue, Elliman and Bedford review the measles, mumps and rubella (MMR) controversy. No data have emerged during the past decade that suggests any link between MMR and neurodevelopmental delays, specifically autism. A recent report in N Engl J Med, that examined the relationship between mercury
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