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Making a difference: the clinical research programme for children
Correspondence to:
Rosalind L Smyth, School of Reproductive and Developmental Medicine, University of Liverpool, Alder Hey Children’s Hospital, Liverpool L12 2AP, UK; r.l.smyth@liv.ac.uk
Accepted 30 April 2007
High quality paediatric clinical research will ensure that tomorrow’s children receive new and better treatments
Keywords: child; medicine; clinical trial
| The first 150 words of the full text of this article appear below. |
All of us involved in the clinical care of children have a duty to improve that care and one way of achieving this is through research. Attention has rightly been drawn to the lack of clinical trials which have addressed issues of relevance to children’s health.1 There are some demoralising statistics to support these arguments. For example, a review of clinical trials published in this journal over 15 years found that a high proportion had important methodological flaws and in around half the sample size was less than 40.2 There are similar findings in paediatric specialities,3 and in community paediatrics only 40% of decisions were supported by research evidence.4 Yet we are all aware of the dramatic impact which the results of clinical trials have had on the care and survival of children with malignant disease and those born preterm. To illustrate the impact of high quality research
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