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Oncology and haematology

G223 DOES TREATMENT OF CHRONIC IDIOPATHIC THROMBOCYTOPENIC PURPURA IN CHILDHOOD MAKE A DIFFERENCE? A SYSTEMATIC REVIEW OF RANDOMISED CONTROLLED TRIALS
EvaStuwe¹, RicharCooke², RusselKeenan¹.¹Royal Liverpool Childrens Hospital, Liverpool, UK; ²Liverpool Womens Hospital, Liverpool, UK

Background: The chronic form of idiopathic thrombocytopenic purpura (ITP) occurs in approximately 10–20% of children with ITP. There is no consensus on the treatment. Life threatening complications of ITP related to bleeding are uncommon but potentially devastating. Spontaneous remissions even after years have been described. No systematic review on the effect of different treatment regimes on morbidity or mortality or prevention of the chronic course of the disease has been completed so far.

Aim: To compare the effect of different treatment regimes or non-treatment on the risk of death and major haemorrhage attributable to chronic ITP and the remission rate.

Method: Randomised controlled trials (RCTs) were identified from the Cochrane Library, PubMed, Medline, Embase, Cinahl, Amed, and reference lists from identified studies and review articles. All RCTs or quasi-randomised trials on the treatment . . . [Full text of this article]

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