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Perinatal medicine

G28 LONGITUDINAL CHANGE IN LACTATE, PH, AND BASE EXCESS IN BLOOD FROM CLAMPED AND UNCLAMPED UMBILICAL CORD VESSELS
L. Armstrong, B. Stenson.The Simpson Centre for Reproductive Health, Edinburgh, UK

Introduction: Umbilical cord lactate is a clinically useful prognostic marker of neurological morbidity. Umbilical cord samples are often delayed, or taken from placental vessels, yet there are no data on how this practice may affect lactate measurement. We studied the effect of delayed sampling in vessels isolated from (clamped), and in continuity with the placenta (unclamped).

Methods: Umbilical cords of placentas obtained immediately after delivery were clamped at five locations. Paired samples were taken from clamped and unclamped vessels at 0, 20, 40, and 60 minutes, and analysed for lactate, pH, PCO₂, and BE. Data were analysed as change from time 0 at 20, 40, and 60 minutes.

Results: n = 38. Lactate was higher than at time zero after 20 minutes in both clamped (p<0.001) and unclamped vessels (p = 0.005). pH is unchanged over 60 . . . [Full text of this article]