LEADING ARTICLE

Correspondence to:
Professor Ieuan A Hughes
Department of Paediatrics, University of Cambridge, Addenbrooke’s Hospital, Box 116, Level 8, Hills Road, Cambridge CB2 2QQ, UK; iah1000@cam.ac.uk

Accepted 31 March 2006

Abbreviations: CAH, congenital adrenal hyperplasia; CAIS, complete androgen insensitivity syndrome; DSD, disorders of sex development; ESPE, European Society for Paediatric Endocrinology; LWPES, Lawson Wilkins Pediatric Endocrine Society; MGD, mixed gonadal dysgenesis; PAIS, partial androgen insensitivity syndrome

Keywords: sex development disorders; gonads; intersex

The birth of an intersex child prompts a long term management strategy that involves a myriad of professionals working with the family. It is estimated that genital anomalies occur in 1 in 4500 births. There has been progress in diagnosis, surgical techniques, understanding psychosocial issues, and recognising and accepting the place of patient advocacy. The Lawson Wilkins Pediatric Endocrine Society (LWPES) and the European Society for Paediatric Endocrinology (ESPE) considered it timely to review the management of intersex disorders from a broad perspective, to review data on longer term outcome, and to formulate proposals for future studies. The methodology comprised establishing several working groups whose membership was drawn from 50 international experts in the field. The groups prepared prior written responses to a defined set of questions resulting from an evidence based review of published reports. At a subsequent gathering of participants, a framework for a consensus document was agreed. . . . [Full text of this article]

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