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Archives of Disease in Childhood 2006;91:551-553; doi:10.1136/adc.2005.087742
Copyright © 2006 BMJ Publishing Group Ltd & Royal College of Paediatrics and Child Health.

PERSPECTIVES

Falling necropsy rates

Falling necropsy rates and risks to public health

W Squier1, J Ironside2

1 Department of Neuropathology, Radcliffe Infirmary, Oxford OX2 6HE, UK
2 Division of Pathology, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK

Correspondence to:
Correspondence to:
Dr Waney Squier
waney.squier@clneuro.ox.ac.uk


Perspective on the paper by Verity et al (see page608)

Keywords: child; necropsy; public health

The first 150 words of the full text of this article appear below.

Dr Verity and his colleagues publish the results of their continuing study of progressive intellectual and neurological deterioration (PIND) in childhood1. The most surprising aspect of this study is the low rate of necropsies in this carefully followed group of children; only four of the 46 deaths were examined after death. This is an obstacle to detection of variant CJD (vCJD). Although most of this group of children had undergone investigations in life that allow a "probable" diagnosis to be made in the adult population, detailed neuropathological study remains the only way to confirm this diagnosis. Although the annual incidence of new cases of variant CJD has declined overall since 1999, more onsets have been observed in 2004 than in 2003, suggesting that it is premature to assume that this disease will soon disappear.2 Furthermore, the age specific incidence of variant CJD has remained essentially unchanged . . . [Full text of this article]


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