PERSPECTIVE
Endocrinology
Parsing ketotic hypoglycaemia
Correspondence to:
Correspondence to:
Dr C A Stanley
Division of Endocrinology, Children’s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19026, USA; stanleyc@email.chop.edu
Perspective on the paper by Bodamer et al (see page 483)
Keywords: hypoglycaemia; ketone body
| The first 150 words of the full text of this article appear below. |
It has been a half century since MacQuarrie called attention to the serious issues of paediatric hypoglycaemia with his presidential address to the American Pediatric Society on "idiopathic hypoglycaemia of infancy".1 He pointed out that "idiopathic hypoglycaemia" could lead to seizures or permanent brain damage, and that it might have a genetic basis; however, he speculated that it was unlikely to involve insulin since insulinomas rarely occur in childhood. Over the years, there have been two types of reactions to MacQuarrie’s formulation of "idiopathic hypoglycaemia of infancy". All too often it has been the ostrich approach of assuming that "idiopathic hypoglycaemia" is a specific entity, forgetting that "idiopathic" is the medicalese equivalent of "I dunno!". The second type of response has been to search for underlying causes in children labelled as "idiopathic hypoglycaemia". The latter approach has been much more rewarding, yielding an ever expanding list of new disorders,
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Relevant Article
- Glucose and leucine kinetics in idiopathic ketotic hypoglycaemia
- O A Bodamer, K Hussein, A A Morris, C-D Langhans, D Rating, E Mayatepek, and J V Leonard
Arch. Dis. Child. 2006 91: 483-486.[Abstract] [Full Text] [PDF]
This article has been cited by other articles:
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Marcus, C., Alken, J., Eriksson, J., Blom, L., Gustafsson, J.
(2007). Insufficient Ketone Body Use Is the Cause of Ketotic Hypoglycemia in One of a Pair of Homozygotic Twins. J. Clin. Endocrinol. Metab.
92: 4080-4084
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