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Archives of Disease in Childhood 2006;91:455-456; doi:10.1136/adc.2005.092890
Copyright © 2006 BMJ Publishing Group Ltd & Royal College of Paediatrics and Child Health.

PERSPECTIVE

Infection

Influenza virus associated encephalopathy

R Surtees1, C DeSousa2

1 UCL Institute of Child Health, London, UK
2 Great Ormond Street Hospital for Children, London, UK

Correspondence to:
Correspondence to:
Prof. R Surtees
The Wolfson Centre, Mecklenburgh Square, London WC1N 2AP, UK; R.Surtees@ich.ucl.ac.uk


Perspective on the paper by Hosoya et al (see page 469)

Keywords: encephalopathy; influenza

The first 150 words of the full text of this article appear below.

The neural complications of influenza are shown in box 1Go. The commonest of these, particularly in young children from Japan and Taiwan, is influenza virus associated encephalopathy. Influenza virus associated encephalopathy is an acute non-inflammatory encephalopathy that presents with seizures and coma on the day, or the day after, influenza symptoms start.1 Influenza is characterised by the abrupt onset of a fever greater than 39°C, respiratory symptoms (rhinorrhoea, cough, and sore throat), myalgia (particularly of the back and limb muscles), and headache.2 In infants symptoms are often lethargy, poor feeding, apnoea, and interstitial pneumonia; older children may also have less specific symptoms of croup, otitis media, diarrhoea, and vomiting.


Box 1: Neural complications of influenza infection

  • Encephalopathy
  • Encephalitis
  • Reye syndrome
  • Febrile convulsion
  • Myelitis
  • Guillaine-Barré syndrome


INFLUENZA VIRUS ASSOCIATED ENCEPHALOPATHY

Influenza virus associated encephalopathy is a disease of young children with a peak incidence between 6 and 18 months of age.1 It has mostly been . . . [Full text of this article]


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