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Endocrinology and diabetes

G33 SEVERE METABOLIC DECOMPENSATION AT PRESENTATION OF DIABETES MELLITUS IN CHILDREN AGED <2 YEARS
P. Paul, A. Ghatak, S. Kerr, C. Smith, M. Didi, J. C. Blair.Royal Liverpool Children’s hospital, Alder Hey, Liverpool, Liverpool, UK

Introduction: The incidence of cerebral oedema at presentation of diabetes mellitus is increased in children aged <2 years and those with severe diabetic ketoacidosis. Here we present a 10 year review of the metabolic profile of children aged <2 years at presentation of diabetes mellitus and report increased incidence of diabetic ketoacidosis and more profound metabolic decompensation than in older prepubertal children.

Patients and Methods: Blood pH, base deficit (BD), serum glucose (Glu), sodium (Na), osmolality, and urea at presentation of diabetes mellitus was studied in 21 children (11 female, age (mean (1 SD)) 1.39 (0.30) year) diagnosed between 1994 and 2003. Each child was matched to one or more pre-pubertal control subjects (25 male:19 female, age 8.05 (1.73) year) diagnosed with diabetes mellitus during the same week.

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