© 2005 BMJ Publishing Group & Royal College of Paediatrics and Child Health
PERSPECTIVE
Pregnancy
Maternal phenylketonuria: the importance of early control during pregnancy
Correspondence to:
Correspondence to:
Dr R Koch
Principal Investigator, Maternal PKU Collaborative Study, Los Angeles, California, USA; rkoch8@earthlink.net
Commentary on the paper by Lee et al (see page 143)
Keywords: maternal phenylketonuria; phenylalanine; pregnancy; outcome
| The first 150 words of the full text of this article appear below. |
Drs Lee, Ridout, Walters, and Cockburn have reviewed data on 228 pregnancies occurring in women with phenylketonuria (PKU).1 This paper provides important data which support the main findings of the Collaborative Maternal PKU Study sponsored by the National Institute of Child Health and Human Development in Bethesda, Maryland, USA.2 Despite the fact that the data of Dr Lee et al are based on pregnancies occurring only in the United Kingdom, the findings verify two of the most important findings in our longitudinal, prospective study, which collected data from three different countries: the United States, Canada, and Germany. In any international study such as the latter, cultural and social differences can always interfere with statistical analyses. Therefore the fact that both studies support and concur that pregnancies in control by the first 10 weeks of pregnancy resulted in normal intellectual development in the offspring at 6–8 years is important information.
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Arch. Dis. Child. 2005 90: 143-146.[Abstract] [Full Text] [PDF]
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