© 2004 BMJ Publishing Group & Royal College of Paediatrics and Child Health
LEADING ARTICLE
Diabetes
Understanding the rising incidence of type 2 diabetes in adolescence
1 Paediatric Endocrine Unit, University Hospital, Lille, France
2 Institute of Biology–CNRS UMR 8090, Institut Pasteur de Lille, Lille, France
3 Paediatric Department, Saint-François d’Assise Foundation, Saint-Denis, Réunion Island, France
Correspondence to:
Correspondence to:
Prof. P Froguel
Institute of Biology–CNRS 8090, Institut Pasteur de Lille, 1 rue Calmette, 59 000 Lille, France; philippe.froguel@mail-good.pasteur-lille.fr
A focus on its epidemiology, pathology, and therapeutic consequences
Keywords: epidemiology; pathology; type 2 diabetes; adolescence
| The first 150 words of the full text of this article appear below. |
The definition of diabetes mellitus (DM) was recently changed by the American Diabetes Association to a fasting plasma glucose value of at least 126 mg/dl (6.9 mmol/l), on the basis of increased risk of the complication of retinopathy.1 It has been estimated that worldwide approximately 154 million people have diabetes,2 with up to one third of the cases remaining undiagnosed in developed countries such as the USA.3 Its human cost is considerable with morbidity from retinopathy, neuropathy, renal failure, and vascular disease, in addition to the socioeconomic burden. Additional lifetime health costs attributable to DM have been estimated at £19 649 per affected individual in the UK.4
Since the introduction of insulin therapy, a clear distinction has been established between the form of DM where insulin is immediately needed (type 1 or insulin dependent DM), and that where there is a danger of hypoglycaemia, where insulin therapy represents a
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