CASE REPORT

Ibuprofen and acute renal failure in a toddler

N E Moghal¹, S Hegde¹, K M Eastham²

¹ Department of Paediatric Nephrology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
² Department of Child Health, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK

Correspondence to:
Correspondence to:
Dr N E Moghal
Consultant Paediatric Nephrologist, Department of Paediatric Nephrology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK; n.e.moghal@ncl.ac.uk

Accepted 12 July 2003

Keywords: acute renal failure; brufen; ibuprofen

The first 150 words of the full text of this article appear below.

Ibuprofen and paracetamol are equally effective¹ and widely used antipyretic agents in paediatric practice. There is no evidence to support the concept that treating a fever with antipyretics, paracetamol, or ibuprofen, will prevent febrile convulsions.² Ibuprofen is available over the counter and is used in addition to or instead of paracetamol both in hospital and community settings. It is advertised on television. There is an increasing trend to routinely prescribe both drugs for children specifically to manage fever. Although it is considered to be a reasonably safe drug,³ there are reports of nephrotoxicity,^4,5 including renal failure when ibuprofen is administered to volume depleted children.⁶

A previously well, 18 month old, 10.5 kg boy presented with a four week history of intermittent cough and wheeze. In the week prior to admission he developed a fever, increasing lethargy, anorexia, and refusing to drink adequately. His fever was initially treated with paracetamol (5 . . . [Full text of this article]

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This article has been cited by other articles:

• John, C. M., Shukla, R., Jones, C. A (2009). Using non-steroidal anti-inflammatory drugs (NSAIDs) in volume depleted children can precipitate acute renal failure. BMJ Case Reports 2009: bcr1220081318-bcr1220081318 [Abstract] [Full Text]  
• El-Radhi, A S. M (2008). Why is the evidence not affecting the practice of fever management?. Arch. Dis. Child. 93: 918-920 [Full Text]  
• Hay, A. D, Costelloe, C., Redmond, N. M, Montgomery, A. A, Fletcher, M., Hollinghurst, S., Peters, T. J (2008). Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): randomised controlled trial. BMJ 337: a1302-a1302 [Abstract] [Full Text]  
• Moghal, N E, Shenoy, M (2008). Furosemide and acute kidney injury in neonates. Arch. Dis. Child. Fetal Neonatal Ed. 93: F313-F316 [Abstract] [Full Text]  
• Mathews John, C., Shukla, R., Jones, C. A (2007). Using NSAID in volume depleted children can precipitate acute renal failure. Arch. Dis. Child. 92: 524-526 [Abstract] [Full Text]  
• Erlewyn-Lajeunesse, M D S, Coppens, K, Hunt, L P, Chinnick, P J, Davies, P, Higginson, I M, Benger, J R (2006). Randomised controlled trial of combined paracetamol and ibuprofen for fever. Arch. Dis. Child. 91: 414-416 [Abstract] [Full Text]  
• Anochie, I C, Eke, F U (2006). Paediatric acute peritoneal dialysis in southern Nigeria.. Postgrad. Med. J. 82: 228-230 [Abstract] [Full Text]  

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