© 2004 BMJ Publishing Group & Royal College of Paediatrics and Child Health
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Should nifedipine be used to counter low blood sugar levels in children with persistent hyperinsulinaemic hypoglycaemia?
Report by Edited by Bob Phillips
1 Department of Pediatric Nephrology, Charité, Humboldt University, Berlin, Germany
2 Department of Pediatric Nephrology, Charité, Humboldt University, Berlin, Germany
3 Department of Neonatology, Charité Campus Mitte, Humboldt University, Berlin, Germany; christoph.roehr@charite.de
Keywords: nifedipine; hypoglycaemia
| The first 150 words of the full text of this article appear below. |
A 5 year old boy, suffering from hyperinsulinaemic hypoglycaemia since infancy and arterial hypertension secondary to polycystic kidney disease, was given nifedipine (0.3 mg/kg three times a day) to treat his high blood pressure. Normotension was restored and his blood sugar levels normalised. We wondered whether nifedipine could be used safely as long term treatment to counter hypoglycaemia in persistent hyperinsulinaemic hypoglycaemia of infancy (PHHI)?
In a child with persistent hyperinsulinaemic hypoglycaemia of infancy [patient], can nifedipine [intervention] safely be given to treat hypoglycaemia [outcome]?
Search terms: "persistent hyperinsulinemic hypoglycaemia of infancy" and "hyperinsulinism" and "nifedipine" and "safety" and "calcium antagonist".
Cochrane Library (nifedipine or persistent hyperinsulinemic hypoglycaemia of infancy): no relevant study found. PubMed (limits: language English; age 0–18 years): one practice guideline,1 six case reports or patient series of PHHI treated with nifedipine,2–7 one report on the safety of calcium channel blockers in children.12 See table
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