HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER		Author Keyword(s) Vol Page [Advanced]

This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this link to a friend Similar articles in ADC Online Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content

Endocrinology and diabetes

G1. SELECTING GIRLS WITH PRECOCIOUS PUBERTY FOR BRAIN IMAGING: EUROPEAN VALIDATION OF AN EVIDENCE-BASED DIAGNOSIS RULE
M. Chalumeau, C.G. Hadjiathanasiou, S.M. Ng, A. Cassio, D. Mul, M. Cisternino, C.J. Partsch, C. Theodoridis, M. Didi, E. Cacciari, W. Oostdijk, A. Borghesi, W.G. Sippell, G. Bréart, R. Brauner.

INSERM U149, Paris-France and Pediatric Endocrinology Departments in Athens-Greece, Liverpool-UK, Bologna and Pavia-Italy, Rotterdam and Leiden-The Netherlands, Kiel-Germany, Paris-France

Background: Central precocious puberty (CPP) reveals an occult intracranial lesion (OICL) in 5–10% of affected girls. Systematic brain imaging is recommended but is normal and then not contributive in 90–95% of the cases. Recently, two American groups formulated distinct guidelines to select girls with CPP who require brain imaging. A previous single-center study found those recommendations to lack sensitivity to identify OICL and had proposed a 100% sensitivity, evidence-based, diagnosis rule, combining two independent predictors of OICL: age at puberty onset (ie, breast development) <6 years, and estradiol (E2) level >45th percentile of girls with idiopathic CPP.

Aim: To validate our . . . [Full text of this article]