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Archives of Disease in Childhood 2003;88:A8
© 2003 BMJ Publishing Group & Royal College of Paediatrics and Child Health


Abstracts

Endocrinology and diabetes

The first 150 words of the full text of this article appear below.


G1. SELECTING GIRLS WITH PRECOCIOUS PUBERTY FOR BRAIN IMAGING: EUROPEAN VALIDATION OF AN EVIDENCE-BASED DIAGNOSIS RULE
M. Chalumeau, C.G. Hadjiathanasiou, S.M. Ng, A. Cassio, D. Mul, M. Cisternino, C.J. Partsch, C. Theodoridis, M. Didi, E. Cacciari, W. Oostdijk, A. Borghesi, W.G. Sippell, G. Bréart, R. Brauner.

INSERM U149, Paris-France and Pediatric Endocrinology Departments in Athens-Greece, Liverpool-UK, Bologna and Pavia-Italy, Rotterdam and Leiden-The Netherlands, Kiel-Germany, Paris-France

Background: Central precocious puberty (CPP) reveals an occult intracranial lesion (OICL) in 5–10% of affected girls. Systematic brain imaging is recommended but is normal and then not contributive in 90–95% of the cases. Recently, two American groups formulated distinct guidelines to select girls with CPP who require brain imaging. A previous single-center study found those recommendations to lack sensitivity to identify OICL and had proposed a 100% sensitivity, evidence-based, diagnosis rule, combining two independent predictors of OICL: age at puberty onset (ie, breast development) <6 years, and estradiol (E2) level >45th percentile of girls with idiopathic CPP.

Aim: To validate our . . . [Full text of this article]







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