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Perinatal medicine

G30. TRANSIENT ADRENOCORTICAL INSUFFICIENCY OF PREMATURITY (TAP) AND SYSTEMIC HYPOTENSION IN VERY LOW BIRTH WEIGHT INFANTS
P.C. Ng, C.H. Lee, C.W.K. Lam, K.C. Ma, T.F. Fok, I.H.S. Chan, E. Wong.

Department of Paediatrics, Department of Chemical Pathology and Centre for Clinical Trials and Epidemiological Research, Prince of Wales Hospital, Chinese University of Hong Kong

Aims: Human corticotrophin releasing hormone (hCRH) stimulation test was used: (i) to determine the relation between pituitary-adrenal response and systemic blood pressure in very low birth weight (VLBW) infants, and (ii) to characterise the endocrinological features of ‘Transient Adrenocortical insufficiency of Prematurity (TAP)’.

Study design: hCRH tests were performed on 137 VLBW infants at day 7 and 14 of life in a tertiary neonatal centre.

Results: Basal and peak serum cortisol at day 7 were associated significantly with the lowest blood pressures recorded during the first two weeks of postnatal age (r > 0.38, p < 0.0001 and r > 0.41, p < 0.0001 for basal and peak levels, respectively). These cortisol . . . [Full text of this article]