© 2003 BMJ Publishing Group & Royal College of Paediatrics and Child Health
Abstracts
Perinatal medicine
| The first 150 words of the full text of this article appear below. |
P.C. Ng, C.H. Lee, C.W.K. Lam, K.C. Ma, T.F. Fok, I.H.S. Chan, E. Wong.
Department of Paediatrics, Department of Chemical Pathology and Centre for Clinical Trials and Epidemiological Research, Prince of Wales Hospital, Chinese University of Hong Kong
Aims: Human corticotrophin releasing hormone (hCRH) stimulation test was used: (i) to determine the relation between pituitary-adrenal response and systemic blood pressure in very low birth weight (VLBW) infants, and (ii) to characterise the endocrinological features of ‘Transient Adrenocortical insufficiency of Prematurity (TAP)’.
Study design: hCRH tests were performed on 137 VLBW infants at day 7 and 14 of life in a tertiary neonatal centre.
Results: Basal and peak serum cortisol at day 7 were associated significantly with the lowest blood pressures recorded during the first two weeks of postnatal age (r > 0.38, p < 0.0001 and r > 0.41, p < 0.0001 for basal and peak levels, respectively). These cortisol
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