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Gastroenterology, hepatology, and nutrition

G14. COMPARISON OF THE EFFECT OF AN OLIVE OIL (CLINOLEIC) AND A SOYA BASED LIPID EMULSION (INTRALIPID) ON PULMONARY HAEMODYNAMICS IN PRETERM INFANTS—RESULTS OF PILOT STUDY
L.S. Miall¹, J.W.L. Puntis¹, D. Thompson².

¹Neonatal Intensive Care Unit, ²Department of Chemical Pathology, Leeds Teaching Hospitals NHS Trust, Leeds, UK

Rationale: Soya based lipid emulsions increase pulmonary pressure in preterm infants. This is thought to be due to production of vasoactive prostaglandins from fatty acids. Emulsions based on olive oil contain less poly-unsaturated fatty acids and may have less effect on pulmonary haemodynamics.

Method: A non-invasive estimate of pulmonary pressure (time to peak velocity /right ventricular ejection time (TPV/RVET)) was performed using echocardiography in preterm infants. Each subject received increasing doses (0 to 3g/kg/day) of either Intralipid or Clinoleic over the first week of life. TPV/RVET was measured at baseline and at maximum dose in each infant. Prostaglandin metabolites thromboxane B2 and 6-keto PGF1 were measured in urine.

Results: 15 infants were studied. 10 received Intralipid and 5 Clinoleic. TPV/RVET increased in both groups with time.(reflecting . . . [Full text of this article]