© 2003 BMJ Publishing Group & Royal College of Paediatrics and Child Health
LETTER
Vitamin K deficient bleeding in cystic fibrosis
York District Hospital, Wigginton Road, York YO31 3HE, UK; David.W.Beverley@york.nhs.uk
Keywords: cystic fibrosis; screening; vitamin K
| The first 150 words of the full text of this article appear below. |
We would like to report a female infant (initially breast fed and subsequently formula fed) who had received two 1 mg doses of vitamin K orally, and presented at 9 weeks of age with large haematomas at the sites of her primary immunisations. Her weight had dropped from the 25th to 50th centile at birth to the 2nd centile.
Her haemoglobin was 720 g/l, white blood cell count 13x109/l, platelet count 523x109/l, prothrombin time >10 seconds (normal range 0.8–1.2), activated partial thromboplastin time 109.4 seconds (normal range 24.0–34.0), and fibrinogen 4.5 g/l (normal range 1.7–4.5). She received 1 mg of vitamin K intravenously and repeat coagulation screen was then normal. Sweat osmolality was 110 mmol/l (normal range 17–80) and 105 mmol/l on repeat testing. No chymotrypsin activity was found in the faeces. DNA analysis confirmed homozygosity for delta F 508.
Vitamin K deficiency can
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This article has been cited by other articles:
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McNinch, A., Busfield, A., Tripp, J.
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