© 2002 Archives of Disease in Childhood
LEADING ARTICLE
Genetics
Family genetic studies
1 Academic Dept of Paediatrics, North Staffordshire Royal Infirmary, Stoke-on-Trent, Staffs, UK
2 Royal Manchester Children’s Hospital, Pendlebury, Manchester, UK
Correspondence to:
Correspondence to:
Dr W Lenney, Academic Dept of Paediatrics, North Staffordshire Royal Infirmary, Stoke-on-Trent, Staffs, UK
Recruitment issues
Keywords: genetics; family; recruitment
| The first 150 words of the full text of this article appear below. |
The success of any clinical study is dependent on the investigators’ abilities to recruit sufficient patients to participate. Consideration of recruitment is important when designing study protocols because by developing complex, detailed inclusion and exclusion criteria, the pool of patients available to include in the study becomes smaller. Having been involved in developing studies from within the pharmaceutical industry, one of us (WL) has worked with over optimistic clinicians convinced they will be able to recruit the required number of patients for a particular study. It is relatively common, however, that studies fail as a result of incomplete recruitment. Information on these failures is impossible to obtain as such studies are never published. Twenty years ago studies were published without appropriate power calculations and with small numbers of patients. Not so today. Recruitment is therefore an important issue as it is acknowledged that even in common diseases such as
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