© 2002 Archives of Disease in Childhood
LEADING ARTICLE
Cisapride
Cochrane's epitaph for cisapride in childhood gastro-oesophageal reflux
The Conway Institute for Biomolecular and Biomedical Research, Department of Paediatrics, University College Dublin, The Children's Research Centre, Our Lady's Hospital for Sick Children, Crumlin, Dublin 12, Republic of Ireland
Correspondence to:
Correspondence to:
Dr B Bourke;
billy.bourke@ucd.ie
Cisapride in childhood gastro-oesophageal reflux
Keywords: gastro-oesophageal reflux disease; cisapride
The coincidental appearance of the Cochrane Review Group's systematic appraisal of the utility of cisapride for gastro-oesophageal reflux (GOR) in children,1 and the withdrawal of this drug in many countries2 could not have been more appropriate. However, there exists a possibility that this serendipitous occurrence will undermine the impact of the Cochrane Review findings. Essentially, the outcome of the study was negative, with no benefits being shown for cisapride in improving the symptoms of GOR in children. In addition, the authors of the report were critical of the quality of data available, noting in particular evidence for substantial publication bias in favour of studies with a positive outcome. Both the immediate and wider implications of the findings of Augood and colleagues1 are deserving of comment.
GOR in young children is a common occurrence. In the vast majority of children reflux is harmless, self limiting, and can be viewed as
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Arch. Dis. Child. 2002 86: 71.
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