Leading article
Reye syndrome
insights on causation and
prognosis
| The first 150 words of the full text of this article appear below. |
 |
Introduction |
|---|
Reye syndrome (RS) is an abrupt insult to mitochondria
manifesting as acute encephalopathy, selective hepatic dysfunction, and
fatty infiltration of the viscera
as originally described in 1963 (see
Wood1). Causation, however, remains unclear, especially the role of aspirin in possible pathogenesis.1 Although
prompt recognition and intensive therapy is essential to full recovery, a paucity of cases in recent years has meant that few younger paediatricians have any personal experience. This and a spate of recent
literatureclinical and scientifichas prompted this review.
| |
Background |
|---|
RS is a biphasic illness. A viral prodromewith infection of the
upper respiratory tract or bowel, or varicellais followed several
days later by an abrupt onset of encephalopathy heralded as profuse,
effortless vomiting. The rate and degree of neurological decline vary.
Raised intracranial pressure from brain swelling is usually thought to
cause death or neurological injury.
The British Paediatric Surveillance Unit defines RS as an
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
-
Westholm, D. E., Stenehjem, D. D., Rumbley, J. N., Drewes, L. R., Anderson, G. W.
(2009). Competitive Inhibition of Organic Anion Transporting Polypeptide 1c1-Mediated Thyroxine Transport by the Fenamate Class of Nonsteroidal Antiinflammatory Drugs. Endocrinology
150: 1025-1032
[Abstract] [Full Text] -
Ishida, T., Sato, T., Irifune, M., Tanaka, K.-i., Nakamura, N., Nishikawa, T.
(2007). Effect of acetaminophen, a cyclooxygenase inhibitor, on Morris water maze task performance in mice. J Psychopharmacol
21: 757-767
[Abstract] -
Juurlink, D. N., Andrade, R. J., Lucena, M. I., Andres, E., Manfredini, R., Boari, B., Gallerani, M., Lee, W. M.
(2003). Drug-Induced Hepatotoxicity. NEJM
349: 1974-1976
[Full Text]
eLetters:
Read all eLetters
- Reye Syndrome: an outdated notion
- Maria Casteels-Van Daele, et al.
- ADC Online, 23 Jan 2002 [Full text]
- Full Text
- Full Text (PDF)
- Submit a response
- Read responses to this article
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in ADC Online
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
