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Archives of Disease in Childhood 2001;84:360-362; doi:10.1136/adc.84.4.360
Copyright © 2001 BMJ Publishing Group Ltd & Royal College of Paediatrics and Child Health.
Arch Dis Child 2001;84:360-362 ( April )
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Fertility preservation for children treated for cancer (2): ethics of consent for gamete storage and experimentation

R Grundya, V Larcherb, R G Gosdenc, M Hewittd, A Leipere, H A Spoudeasf, D Walkerd, W H B Wallaceg

a Institute of Child Health, University of Birmingham, Whittall Street, Birmingham B4 6NH, UK, b Department of General Paediatric Medicine, The Royal London Hospital, Whitechapel, London E1 1BB, UK, c Department of Obstetrics and Gynaecology, Division of Reproductive Biology, 687 Pine Avenue West, Montreal, QC Canada, H3A1A1, Canada, d Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK, e Department of Haematology and Oncology, The Hospital for Sick Children, Great Ormond Street, London WC1N 3JH, UK, f Department of Paediatric and Adolescent Endocrinology and Oncology, The Middlesex Hospital, Mortimer Street, London W1N 8AA, UK, g Department of Haematology and Oncology, Royal Hospital for Sick Children, 17 Millerfield Place, Edinburgh E19 1LF, UK

Correspondence to: Dr Grundy r.g.grundy@bham.ac.uk

Accepted 21 November 2000

The first 150 words of the full text of this article appear below.

    Introduction

Infertility causes significant psychosocial morbidity by reducing both personal sense of wellbeing (health) and capacity to exercise self determination over reproduction (autonomy).1 As the primary moral responsibilities of health professionals are restoration of health and respecting patients' autonomy, it follows that preserving fertility or treating infertility has sound ethical justification in adults. These arguments also apply to children. Children who develop cancer suffer misfortune; for this to be compounded by the burden of potentially treatable infertility seems doubly unjust. However, intervention to preserve fertility must have a sound evidence base as well as moral provenance. It should neither raise unrealistic expectations nor have long term adverse effects on the patient or their offspring.


    Ethics of removal, storage, and manipulation of gonadal tissues

Preservation of fertility by assisted reproductive techniques (ART) is not an established part of cancer treatment for prepubescent children and without relevant research to determine its efficacy and safety it cannot be considered as such. Clinical research . . . [Full text of this article]


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  • Fallat, M. E., Hutter, J., the Committee on Bioethics, Section on Hematology/, (2008). Preservation of Fertility in Pediatric and Adolescent Patients With Cancer. Pediatrics 121: e1461-e1469 [Abstract] [Full Text]  
  • Jaffe, A, Prasad, S A, Larcher, V, Hart, S (2006). Gene therapy for children with cystic fibrosis--who has the right to choose?. J. Med. Ethics 32: 361-364 [Full Text]  
  • Patrizio, P., Butts, S., Caplan, A. (2005). Ovarian Tissue Preservation and Future Fertility: Emerging Technologies and Ethical Considerations. J Natl Cancer Inst Monogr 2005: 107-110 [Abstract] [Full Text]  
  • Wallace, W H B, Thomson, A B (2003). Preservation of fertility in children treated for cancer. Arch. Dis. Child. 88: 493-496 [Abstract] [Full Text]  
  • BAHADUR, G., HINDMARSH, P., RALPH, D. (2001). Fertility preservation in children---scientific advances, research dilemmas, and ethics of consent. Arch. Dis. Child. 85: 442c-442 [Full Text]  

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Re: Fertility preservation for children treated for cancer (2): ethics of consent for gamete storage
G Bahadur, et al.
ADC Online, 26 Jun 2001 [Full text]

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