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Arch Dis Child 2001 Volume 84 No 3
In 1992, the paediatric network for treatment of AIDS (PENTA)
began to recruit children for an RCT of zidovudine (ZDV). As it became
clear in adults that combination therapy was superior to ZDV, the
paediatric trial was terminated in October 1995.
Vital information has nonetheless become available and appears in this
month's ADC (page 230). When the trial was unblinded, parents of
children receiving ZDV were offered a second drug and those who had
received placebo started on combination therapy. One result is that the
trialists are now able to compare the results of children starting
"late" or "early" on mono, dual, or triple therapy.
The authors found no evidence of benefit in favour of early ZDV
monotherapy. At three years from trial entry, 14% of children had
progressed to AIDS or had died. However, progression was significantly lower in 1997-8, probably because more
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