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Limitations of models used to examine the influence of nutrition during pregnancy and adult disease
Michael E Symonds, Helen Budge, Terence Stephenson
Academic Division of
Child Health, School of Human Development, E Floor, University
Hospital, Queen's Medical Centre, Nottingham NG7 2UH, UK
Correspondence to: Dr Symonds email: michael.symonds@nottingham.ac.uk
| The first 150 words of the full text of this article appear below. |
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Introduction |
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Compromised growth in utero is associated with prematurity and
complications after birth. It has been proposed that poor intrauterine growth not only contributes to increased morbidity and mortality during
infancy but also has the potential to compromise adult health and
wellbeing.1 Over the past decade, epidemiological studies
in several countries have shown that size at birth and/or placental
weight predict adult health and disease.1-3 It has also
been proposed that maternal undernutrition at critical stages of
gestation can affect fetal growth and body shape. These effects may be
mediated in part by changes in placental growth, as some studies have
suggested that fetal:placental weight ratio at birth is a predictor of
adult disease.4 Fetal:placental weight ratio in healthy
human pregnancies at term is approximately 5:1 but disease states can
lead to alterations in this ratio. Intrauterine growth restriction is
often accompanied by a light placenta in both humans and
sheep,5
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