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Arch Dis Child 2000;83:98-101 ( August )

Leading article

Intracytoplasmic sperm injection and other aspects of new reproductive technologies

The first 150 words of the full text of this article appear below.

	Introduction

Louise Brown was 21 in 1999. Since her birth, in vitro fertilisation (IVF) has become a widely used treatment for the subfertile couple. Currently about 1% of births in the United Kingdom follow conceptions in vitro. Certain forms of subfertility, largely those derived from male problems (affecting up to 40% of subfertile couples), cannot be treated by conventional IVF, and the development of intracytoplasmic sperm injection (ICSI) has allowed some of these couples to conceive.

	What is ICSI?

ICSI was developed in humans in Belgium in 1992.¹ The procedure involves injecting a single sperm into an egg using a micropipette one fourteenth the diameter of a human hair. The spermatozoa can be obtained either after ejaculation or after aspiration (directly) from the testis or epididymis (percutaneous epididymal sperm aspiration). The spermatozoa are prepared by washing away seminal plasma and, where possible, separating the progressive (most) motile sperm from cellular debris. Poorly motile or abnormally shaped . . . [Full text of this article]

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