Leading article
Leptin and puberty
| The first 150 words of the full text of this article appear below. |
 |
Introduction |
|---|
Our knowledge of the potential genetic link between fat metabolism and the reproductive axis dates back to the 1950s when the obese (ob/ob) mouse strain was first described. These mice were not only distinctly hyperphagic and rapidly developed obesity associated with hyperglycaemia and insulin resistance, but they were also infertile.1 It was not until 1994 when the leptin (ob) gene was postionally cloned and a mutation was identified in the coding sequence of murine leptin in ob/ob mice that the cause of their obesity was recognised.2 As predicted from the phenotype of ob/ob mice, leptin, which is principally expressed in adipocytes, had potent actions to suppress appetite and stimulate energy expenditure. It rapidly became clear that leptin could also influence the reproductive system. The sterility of male and female ob/ob mice could be reversed when recombinant leptin was administered.3 4
In humans, initial studies focused on the possible
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
-
Bonjour, J.-P., Chevalley, T.
(2007). Pubertal Timing, Peak Bone Mass and Fragility Fracture Risk. IBMS BoneKEy
4: 30-48
[Abstract] [Full Text] -
Chevalley, T., Rizzoli, R., Hans, D., Ferrari, S., Bonjour, J.-P.
(2005). Interaction between Calcium Intake and Menarcheal Age on Bone Mass Gain: An Eight-Year Follow-Up Study from Prepuberty to Postmenarche. J. Clin. Endocrinol. Metab.
90: 44-51
[Abstract] [Full Text] -
Bohm, B, Katz-Salamon, M
(2003). Cognitive development at 5.5 years of children with chronic lung disease of prematurity. Arch. Dis. Child. Fetal Neonatal Ed.
88: F101-F105
[Abstract] [Full Text]
- Full Text
- Full Text (PDF)
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in ADC Online
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
