Letters to the editor
IGFBP-3 as a predictor of growth hormone deficiency
| The first 150 words of the full text of this article appear below. |
EDITOR,
We read with interest the paper by
Mitchell and colleagues1 and wish to add our own
observations on this subject. In 1996 the Regional Endocrine Laboratory
started to provide a service for the measurement of insulin-like growth
factor binding protein (IGFBP-3) following early reports that this was
a good marker of growth hormone secretion. We then undertook a
retrospective audit of the measurement of serum insulin-like growth
factor (IGF-1) and IGFBP-3 as predictive markers of growth hormone
deficiency (GHD) in children undergoing growth hormone stimulation
tests (glucagon and insulin tolerance tests). Between October 1996 and January 1998, 93 children had simultaneous measurements of IGF-1 and 78 children had measurements of IGFBP-3. We defined GHD as a peak growth
hormone level of < 20 mU/litre and complete GHD as a peak
< 10 mU/litre in response to a stimulation test.
The results for IGF-1 and IGFBP-3 were compared to reference ranges for
age available in the laboratory
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