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Is prolonged rotavirus infection a common cause of protracted diarrhoea?
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Before Ruth Bishop's identification in Melbourne of human
rotavirus in 1973, paediatricians could offer only platitudes by way of
explanation when confronted with young children with acute diarrhoea.
Since then it has become clear that rotavirus is the most common cause
of gastroenteritis in children under 2 years of age living in either
developed or developing countries.1 Its pathogenic
mechanisms have been largely elucidated, mainly by studying an
analogous infection in piglets caused by transmissible gastroenteritis
agent.2 3 Rotavirus probably causes diarrhoea by
increasing the turnover of enterocytes along the villus axis, leading
to the population of blunted villi by immature cells that are incapable
of normal absorption, and are more crypt-like and secretory in
nature.4-6 Rotavirus can also reduce
sucrase-isomaltase expression in human enterocytes by blocking
sucrase-isomaltase transport to the apical membrane without apparent
cell destruction. Reduction in activity is correlated to rotavirus
induced alterations in the enterocyte cytoskeleton.7 There
is also
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This article has been cited by other articles:
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WALKER-SMITH, J A, PHILLIPS, A D
(1999). Is prolonged rotavirus infection a common cause of protracted diarrhoea?. Arch. Dis. Child.
81: 189j-189
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