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Archives of Disease in Childhood 1999;80:3-6; doi:10.1136/adc.80.1.3
Copyright © 1999 BMJ Publishing Group Ltd & Royal College of Paediatrics and Child Health.
Arch Dis Child 1999;80:3-6 ( January )

Annotation

Umbilical cord blood transplantation

The first 150 words of the full text of this article appear below.

    Introduction

Since Gluckman et al's first description of successful haemopoietic stem cell transplantation using umbilical cord blood (UCB) as the source of marrow progenitors in 1989,1 more than 500 umbilical cord blood stem cell transplants have been performed. Umbilical cord blood banks have been set up in the USA and Europe to store these cells, which in the past have been considered a waste product of reproduction. Although most UCB haemopoietic stem cell transplants have taken place in the past three years, recently published reports2-5 have given an important insight into the clinical potential of UCB as a source of haemopoietic progenitor cells for transplantation.

Allogeneic bone marrow transplantation (BMT) can potentially be used to cure a variety of diseases including haematological malignancies, bone marrow failure syndromes, haemoglobinopathies, immunodeficiencies, and some inborn errors of metabolism.6 The use of allogeneic BMT is limited by the need for adequate tissue matching of . . . [Full text of this article]


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This article has been cited by other articles:

  • JONES, C A, WARNER, J O (1999). Umbilical cord blood transplantation. Arch. Dis. Child. 81: 278l-278 [Full Text]  

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